We help companies solve complex scientific challenges

Reliable image analysis software

TotalLab is a global pioneer and leader in software development for image analysis.

We were founded in 2013 when we evolved out of Nonlinear Dynamics, after it was acquired by Waters Corporation. We have maintained and built upon our ability to create bespoke software and OEM software for data analysis, enabling labs to have confidence in the results of their analysis.

The evolution of gel electrophoresis software

Following the acquisition of Nonlinear Dynamics, we started to work more closely with the pharmaceutical industry. We focused on our 2D software, SpotMap, which was developed to meet the time critical needs of this industry. Our software enables academic researchers and those in industry to make informed choices, for instance when choosing antibodies for host cell protein detection in advanced therapeutics. Since its launch in 2015 it has now become the industry standard for HCP coverage analysis.

We also offer SameSpots, a 2D gel analysis statistics software package which identifies differential protein expression and enables you to easily export ‘spots’ of interest for further analysis with mass spectrometry.

CLIQS is our 1D gel image analysis software which enables evaluation of DNA, RNA and protein samples, including Western Blot analysis.

Based in the UK with a global reach

Based in Newcastle upon Tyne in North East England, we work with clients around the world, providing solutions and expertise in image analysis. We also support companies in achieving and maintaining regulatory compliance, including 21 CFR part 11 and EU Annex 11. Learn more about our GxP solution and its integration with our 1D and 2D analysis software here.

We pride ourselves on being responsive and reactive to the questions and requirements of our clients and partners. Through listening to our customers and applying feedback, we have continuously improved and developed our portfolio.

And as we have decades of both industry and software experience, our clients feel confident and safe in the knowledge that our products are tried and tested to deliver fast, accurate and reliable results via an easy-to-use platform.

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CLIQS 1D Pro | How to create dendrograms for similarity

CLIQS 1D Pro allows the building of a database of lanes and bands extracted from images of 1D gels and blots. Here we demonstrate how to visualise the similarities between lanes in the form of dendrogams or similarity tables.

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SameSpots | How to assign protein isoelectric point and molecular weight to spots

Learn how to add pI and MW info into SameSpots for automatic calculation of molecular weight for all identified spots.

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CLIQs 1D Pro | How to Accurately Match Bands/Compare Lanes Across Different Gels and Blots

Watch how CLIQS 1D Pro can perform a simple comparison between lanes taken from different gels or blots, to identify any matches between them.

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SpotMap | How to Analyse Host Cell Protein (HCP) Antibody Coverage %

This tutorial will show you how to analyse 2D gel electrophoresis and western blot images using TotalLab's SpotMap HCP image analysis software and calculate a percentage coverage score.

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Phoretix 1D | How to Choose the Right Background Removal Method for Your Image Analysis

In this demo, we explain the difference between our background removal techniques and how to choose the correct one based on your data.

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Phoretix 1D | How to Automate Your Western Blot or Gel Electrophoresis Analysis

The automatic analysis features built into Phoretix 1D can save you huge amounts of time in a high-throughput environment and minimise inter-operator and inter-lab variability.

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